Association between Hscrp Levels and Glycemic Control with Total Interatrial Conduction Time in Type 2 Diabetes Mellitus Patients


Isyana Miranti K, Trisulo Wasyanto, Bhisma Murti

Masters Program in Family Medicine, Sebelas Maret University
Department of Cardiology, Faculty of Medicine/ Dr. Moewardi Hospital, Surakarta
Masters Program in Public Health, Sebelas Maret University

ABSTRACT

BACKGROUND:
Type 2 Diabetes Mellitus (T2DM) represents one of the most important risk factors for atrial fibrillation (AF). Numerous studies have shown that T2DM and poor glycemic control reflected by glycated hemoglobin A1c (HbA1c) levels are independently associated with AF onset. Recent experimental studies reported that the increased susceptibi-lity to AF in the diabetic patients was presumably due to the slowing con-duction associated with increased interstitial fibrosis. Systemic inflame-mation can play role in the development of atrial fibrillation. High-sensitivity C-reactive protein (HsCRP) is an inflammatory biomarker that independently predicts the cardiovascular risk. This study aimed to analy-ze the association between HsCRP level, glycemic control, and total intera-trial conduction time in T2DM patients.

SUBJECT AND METHODS: This was an analytic cross sectional study. A total of 41 patients with T2DM were evaluated. HsCRP and HbA1c were measured from peripheral venous blood samples taken from these patients. The total interatrial conduction time was measured by tissue Doppler echocardiography. Multiple regression analysis was use to analyzed the data.

RESULTS: The high-sensitivity C-reactive protein level was higher in the T2DM patients with HbA1c≥7% (0.44±0.30) than in the T2DM patients with HbA1c<7% (0.32±0.22), although statistically non-significant (p=0.183). The total atrial conduction time (milliseconds) was longer in the T2DM patients with HbA1c≥7% (100.29±28.53) than in T2DM patients with HbA1c<7% (94.88±16.50), although statistically non-signifi-cant (p=0.449). Multiple regression analysis showed that HsCRP level (b=38.78; 95%CI=14.01 to 63.54; p=0.003) and glycemic control (b=14.04; 95%CI=0.09 to 27.98; p=0.048) had positive association with total interatrial conduction time in T2DM patients.

CONCLUSION:
HsCRP level and glycemic control had significant positive association with total interatrial conduction time in T2DM patients.

Keywords: HsCRP, glycemic control, HbA1c, total interatrial conduction time.

DOI: https://doi.org/10.26911/theicph.2016.066

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