A Path Analysis on the Biopsychosocial Determinants of Multi Drug Resistant Tuberculosis in Surakarta


Lina Alfiyani1), Setyo Sri Rahardjo2), Bhisma Murti1)

1)Masters Program in Public Health, Universitas Sebelas Maret

2)Faculty of Medicine, Universitas Sebelas Maret

 

ABSTRACT

Background: Multidrug-resistant tuberculosis (MDR-TB) causes significant problem and cost for national TB control program. MDR-TB constitutes an increasing public health concern globally. The prevalence of MDR-TB is as high as 50%. One third of all newly detected TB patients are infected with MDR strains. This study aimed to analyze the bio-psychosocial determinants of MDR-TB in Surakarta, Central Java.

Subjects and Method: This was a case control study conducted in Dr. Moewardi Hospital and BBKPM, Surakarta, from September to November 2017. A sample consisting of 76 MDR-TB patients and 228 non MDR-TB patients were selected for this study by fixed disease sampling. The dependent variable was MDR-TB. The independent variables were age, drug-taking adherence, depression, comorbidity, drug side-effect, drug-taking supervisor, and family income. The data were collected using a set of questionnaire and analyzed by path analysis.

Results: MDR-TB directly increased with the lack of drug-taking adherence (b= -1.7; 95% CI= -2.23 to -1.07; p= 0.001) and comorbidity (b= 1.5; 95% CI= 0.76 to 2.30; p= 0.001). MDR-TB indirectly increased with depression, drug side effect, weak drug-taking supervision, and older age.

Conclusion: MDR-TB directly increases with the lack of drug-taking adherence and comorbidity. MDR-TB indirectly increases with depression, drug side effect, weak drug-taking supervision, and older age.

Keywords: bio-psychosocial determinants, MDR-TB

Correspondence: Lina Alfiyani. Masters Program in Public Health, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta, Central Java. Email: linabbt@gmail.com.

DOI: https://doi.org/10.26911/mid.icph.2018.01.03

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