Does Vitamin C Affect HbA1c?

Dwi Astuti Dian Andarwati1), Bhisma Murti2)Endang Sutisna Sulaeman2)


1)Masters Program in Nutrition, Universitas Sebelas Maret

2)Masters Program in Public Health, Universitas Sebelas Maret



Background: Diabetes is a chronic disorder associated with disturbances in carbohydrate, fat, and protein metabolism characterized by hyperglycemia. HbA1c is used to monitor long-term glycemic control, adjust therapy, assess the quality of diabetes care, and predict the risk for the development of compli­cations. Early studies showed that vitamin C increases inflammation and oxidative stress as a strategy to prevent diabetes. This study aimed to examine the effect of vitamin C on HbA1c.

Subjects and Method: This was a literature review study. The literature was ob­tained from ScienceDirect, PubMed, and Google Search. After screening of articles published from 2000 to 2018 using keywords “HbA1c” and “vitamin C”, the au­thor obtained 21 articles. The study population was diabetic and non-diabetic patients.

Results: Almost all research articles under review showed inverse relationship bet­ween vitamin C and HbA1c. That said, the higher vitamin C consumption, the lower HbA1c. This is because vitamin C can reduce microvascular complication and cardiovascular disorder in diabetic and non-diabetic patients. In non-diabetic pa­tients, vitamin C can reduce the risk of diabetes. In diabetic patients, it can reduce the risk of diabetes complication.

Conclusion: High dose of vitamin C decreases HbA1c level. Vitamin C can help re­duce risk of diabetes as well as diabetes complications.

Keywords: diabetes, HbA1c, vitamin C

Correspondence: Dwi Astuti Dian Andarwati. Masters Program in Nutrition, Universitas Sebelas Maret, Surakarta 57126, Central Java. Email: Mobile: 081329588344.


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