Immunodepression As a Risk Factor of Infection in Patients with Acute Ischemic Stroke

Ken Wirastuti1,2)


1)Faculty of Medicine, Universitas Sultan Agung

2)Sultan Agung Islamic Hospital



Background: Immunodepression is an absence or deficient supply of the com­po­nents of either humoral or cellular immunity, or both. Previous studies show that the central nervous system and the immune system interact in complex ways. Bet­ter insight into these interactions may be relevant to the treatment of patients with stroke and other forms of central nervous system injury. This study aimed to deter­mine immunodepression as a risk factor of infection in patients with acute ischemic stroke.

Subjects and Method: This was a cohort study conducted in Sultan Agung Isla­mic Hospital, Semarang, Central Java. A sample of 89 patients with post-acute ischemic stroke who had been hospitalized for ≥5 days was selected for this study as the exposed group and non-stroke patients as non-exposed group. The dependent variable was immunodepression infection as indicated by high leucocytes, high neutrophils, low lymphocytes, low monocytes. The independent vari­able was post-acute ischemic stroke. The data were obtained from the medical re­cord. The data were analyzed by a chi-square test with Risk Ratio (RR) as the mea­sure of association.

Results: Post-acute ischemic stroke was associated with an increased risk of leucocytosis (RR= 3.95%; 95% CI= 1.59 to 3.27), neutrophilia (RR= 1.98; 95% CI= 1.69 to 12.63), lymphocytopenia (RR= 1.77; 95% CI= 1.51 to 1.98), mono­cytopenia (RR= 1.85%; 95% CI= 1.33 to 1.92).

Conclusion: Acute ischemic stroke increases the risk of infection due to immuno­depression.

Keywords: acute ischemic stroke, immunodepression, infection

Correspondence: Ken Wirastuti. Faculty of Medicine, Universitas Sultan Agung/ Sultan Agung Islamic Hospital. Email: Mobile: 08122716132.



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