Correlation of Excess Secondary Iron and Stunting in Children with Thalassemia


Adhitama AP1), Pasaribu MM2),4), Yanti N1), Anandari L4), Kosen DN 4), Timan IS2),4)

 

1)Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo General Hospital, Jakarta

2)Department ofClinical Pathology, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo  General Hospital, Jakarta

3)Department of Neurology, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo General Hospital, Jakarta

4)Human Genetic Research Cluster, Indonesia Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta

 

ABSTRACT 

Background: Growth disorders in children with thalassemia major are in­fluenced by ma­ny factors. High serum ferritin levels in puberty were reported to cause short stature and de­layed body growth in thalassemic major patients. The purpose of this stu­­dy was to de­termine the corre­lation of excess secondary iron and stunting in children with thalassemia.

Subjects and Method: This was a cross sectional study conducted at Cipto Ma­ngun­ku­su­mo General Hospital, Jakarta. A sample of 109 children aged less than 18 diag­no­sed with tha­las­semia was selected for this study. The dependent variable was stun­ti­ng. The in­de­pen­dent va­riable was ferritin serum, hemoglobin levels, hematocrit levels and height. Corre­la­ti­on bet­ween fer­ritin and stunting was measured by Pearson correlation.

Results: As many as 53 (48.6 %) of total 109 children had stunting, consisting of 22 boys 31 girls. Mean (SD) age was 10.13 (4.78) years. Mean (SD) body height was 129.08 (23.68) cm. Mean (SD) ferritin level in stunting group was 3938.6 (402.9) ng/dL and in non-stunt­ing group was 3548.9 (381.5) ng/dL. Mean (SD) hemoglobin level in stunting group and non-stunting group was 8.4 (0.3) g/dL and 8.7 (0.1) g/dL. Mean (SD) hema­tocrit level in stu­n­ting group was 25 % (0.5 %) and in non-stunting group was 26.1% (0.4 %).  Excess fe­rr­itin was positively correlated with stunting (r=0.28; p=0.010).

Conclusion: Serum ferritin level is positively associated with stunting in children aged less than 18 years.

Keywords: thalassemia, hemochromatosis, stunting, ferritin

Correspondence: Adhitama AP. Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo General Ho­­s­­pital, Jakarta. Email: ina_st_ui@yahoo.com. Mobile: 0811-143-090

DOIhttps://doi.org/10.26911/theicph.2019.03.29

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