Decline in Antibiotic Use after Implementation of Restriction Program at Eka Hospital, Pekanbaru, Riau Martin Susanto1, Puput OktamiQanti1, Dewi Anggraini2, Winda Gusti Enda2 1)Masters Program of Public Health, Universitas Indonesia 2)Eka Hospital, Pekanbaru ABSTRACT Background: Antimicrobial agents are among the most frequently and inappropriately prescribed medications worldwide. Broad evidence indicates that approximately 64% of all hospitalized patients receive antibiotic drugs during their hospital stay. It has been reported that more than half of antibiotics may be inappropriately prescribed. With the high volume of broad spectrum antibiotics prescribed, there may be severe consequences if simple management of prescribing habits is not initiated. Unnecessary use of antibiotics can contribute to the development of antimicrobial resistance leading to possible development of suprainfections. This study aimed to examine the decline in antibiotics use after implementation of restriction program at Eka Hospital, Pekanbaru, Riau. Subjects and Method: This was a quasi experiment before and after with no control design. This study was conducted at Eka Hospital, Pekanbaru, Riau on January 2017 to September 2018. A sample of in-patient was selected for this study by total sampling. The sample covered before restriction program (January to September 2017) and after restriction program (October 2017 to September 2018). The dependent variable was quantity of antibiotic use rated in units DDD100 (defined daily dose). Antibiotics that are restructured are third-line antibiotics whose use must be controlled and determined by the antimicrobial resistance control (PPRA), namely meropenem, doripenem, imipenem, vancomycin, linezolid, cefepime, tigecycline and amikacin. The independent variable was antibiotics restriction program. The data were collected by electronic medical record. Results: There was an average decrease in DDD100 (in parenthesis) from previous year to restriction program has been effective, including six antibiotics that were restrained, namely meropenem (3.39 to 2.71), doripenem (0.43 to 0.08), imipenem (29 to 0.04), cefepime (1.53 to 0.28), amikacin (1.33 to 0.86), and tigecycline (0.71 to 0.58). There was an increase in vancomycin (0.27 to 0.40), and there was no linezolid prescription from 2017 to 2018. Antibiotics included meropenem (p=0.039), imipenem (p= 0.020) doripenem (p= 0.003) and cefepime (p= 0.001) were statiscally significant with decrease quantity of antibiotic use. Conclusion: Antibiotics restriction program is effective to reduce unnecessary use of antibiotics. Altering antibiotics prescription practices through guideline development, restricting antibiotic usage through PPRA, and narrowing the spectrum of antibiotics have all shown varying degrees of effectiveness. Keywords: antibiotics stewardship program, restriction, DDD Correspondence: Martin Susanto. Masters Program of Public Health, Universitas Indonesia. Email: susanto.martin@gmail.com. Mobile: 0811153642. DOI: https://doi.org/10.26911/theicph.2019.04.44 ← → x × Share this : View PDF