Effect of Antenatal Mental Health Disorder on Fetal Growth:A Systematic Review

Rina Tri Handayani


School of Health Sciences Mamba’ul ‘Ulum, Surakarta



Background: Maternal mental disorders during pregnancy are associated with a range of ad­verse health outcomes for infants. Recent studies indicate the possible me­chanisms of maternal mental health disorder associated with fetal development through programming effects. The pur­pose of this study was to review systematically the effect of antenatal mental health disorder on fetal growth.

Subjects and Method: The study was con­ducted from July to September 2018.A systematic review was carried out by searching articles from PsycINFO, Medline, Web of Science, Embase, and Scopus. The keywords for this review includedmaternal mental health AND fetal growth, post­­partum depression AND fetal growth, maternal mental health AND fetal growth AND. As ma­ny as 11 articles were selected for this study from 575 articles.

Results: Maternal mental health during pregnancy was associated with fetal head cir­cum­fe­rence growth through 2 mechanisms: (1) Increased maternal stress response modifies neu­ro­en­docrine function, which included changes in cortisol regulation, adrenocorticotropic, adrenaline, and noradrenaline hormones level; and (2) Decreased 11β-hydroxysteroid dehydro­genase (11β-HSD2) enzyme regulation in placenta. It decreased 11β-HSD2 level, increased fetal glu­co­cor­ticoid circulation, and affected on fetal head growth restriction.

Conclusion: Maternal mental health during pregnancy is associated with fetal head cir­cum­ference growth restriction.

Keywords: maternal mental health, fetal head circumference, growth

Correspondence: Rina Tri Handayani. School of Health Science Mamba’ul ‘Ulum. Jl. Ring Road Utara, Tawangsari, Mojosongo, Jebres, Surakarta, Central Java. Email: trihandayanirina­@gmail.com. Mobile: 085642224141

DOI: https://doi.org/10.26911/theicph.2019.03.62

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