The Best Time to Perform Pleurodesis among Malignant Pleural Effusion Patients


Yusup Subagio, Farih Rahardjo, Wisuda Moniqa, Indarto Sigit, Muhammad Rudianor

 

Department of Pulmonology and Respiration, Faculty of Medicine,

Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta

 

ABSTRACT

Background: Malignant pleural effusion is a common clinical problem in cancer patients. Many therapeutic techniques have been investigated, including pleurodesis. How­­ever, studies on factors that affect the success rate of pleurodesis in Indonesia are scarce. The purpose of this study was to determine the best time to perform pleurodesis a­mong malignant pleural effusion patients.

Subjects and Method:This was an experiment study conducted at Dr. Moewardi hospital, Surakarta, Central Java, from March 1 to April 30, 2017. A sample of 17 malig­nant pleural effusion patients with water sealed drainage (WSD) was selected for this study. All patients were observed 3 times/ day: (1) 07.00 to 14.00; (2) 14.00 to 22.00; and (3) 22.00 to 07.00. Pleurodesis was performed when the amount of pleural fluid is in the lowest level which is at 14.00 to 22.00 during two months observation. The dependent variable was pleural fluid volume. The inde­pen­dent variable was pleura­desis. The data were analyzed by Anova and post hoc test.

Results: The lowest mean pleural fluid volume was achieved at the second observation (Mean= 84.66; SD= 38.88). The highest mean pleural fluid volume was achieved at the first observation (Mean= 111.22; SD= 57.83). The different mean between the first and the second observation was statistically significant (p= 0.032). The mean pleural fluid volume at the third observation was mean= 110.77; SD= 65.57. The different mean between the second and the third was marginally significant (p= 0.073).

Conclusion:The best time to perform pleurodesis is the second observation (14.00 to 22.00).

Keywords:malignant pleural effusion, pleural fluid, pleurodesis

Correspondence: Yusup Subagio. Department of Pulmonology and Respiration, Faculty of Medicine, Uni­­versitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java. Email: dr_­yu­su­psubagio­@yahoo.com.

DOI: https://doi.org/10.26911/theicph.2019.05.34

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