Effectiveness of Cod Liver Oil Emulsion as An Anti-Hyperuricemic Agent in Mice

Stefiani Emasurya Indrajaya, Andreanus A. Soemardji,  Siti Fara Rahmawati


Bandung Instituteof Technology, West Java, Indonesia



Background:Worldwide, the prevalence of hyperuricemia has increased substantially in re­cent decades. The progressive increase in serum levels of uric acid levels may be linked to the rising prevalence of overweight and obesity, as well as the increase in con­sump­tion of sugar-sweetened beverages, foods rich in purines, and alcohol. Cod liver oil contains high levels of eico­sapentaenoic acid (EPA) and docosahexaenoic acid (DHA) as well as vitamins A and D. Ma­ny­ of the benefits of cod liver oil are believed to de­rive from its powerful anti-inflammatory pro­perties. This study aimed to determine the effectiveness of cod liver oil emulsion as an anti-hyperuricemia agent in mice.

Subjects and Method:This was an experiment conducted at the laboratory, Bandung Institute of Technology, in Bandung, West Java. A sample of 24 Swiss Web­ster rats was selected for this stu­dy, and was randomly assigned to 6 groups:  (1) Uric acid induction with high purine food 100 mg/kg BW; (2) Uric acid induction and allo­purinol 26 mg/kg BW dose; (3) Uric acid in­duction and vitamin A 650 IU/kg BW dose; (4) Uric acid induction and cod liver oil emulsion 150 mg/kg BW dose; (5) Uric acid in­duc­tion and cod liver oil emulsion 300 mg/kg BW dose; and (6) Uric acid induction and cod liver oil emulsion 450 mg/kg BW dose. The independent va­ria­ble was cod liver oil emulsion. The dependent variable was uric acid level. The data were ana­lyz­ed by paired t test.

Results: Cod liver oil emulsion of 150, 300, and 450 mg/kg BW doses reduced uric acid as much as 57.10%, 40.83%, and 49.70%.

Conclusion: Cod liver oil emulsion of 150, 300, and 450 mg/kg BW doses are effective tore­duce uric acid in mice.

Keywords: cod liver oil emulsion, anti-hyperuricemic. 

Correspondence: Stefiani Emasurya Indrajaya. Bandung Instituteof Technology, Jl. Ganesha No.10, Lb. Sili­wa­ngi, Coblong, Bandung, West Java 40132. E-mail: stefiani.emasurya@gmail.com. Mobile: 087­­885999499.

DOI: https://doi.org/10.26911/theicph.2019.05.11 

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