Agreement, Sensitivity, and Specificity of Tuberculin Skin Test and T-Spot TB Examination, in Detecting Latent TB Infection among Patients with Diabetes Mellitus


Nur Amalia Santang1), Pribadi M Sebayang1), Reviono1)Supriyanto Kartodarsono2), Yusup Subagio Sutanto1)

 

1)Department of Pulmonology and Respiratory Medicine, Dr. Moewardi Hospital Surakarta, Central Java

2)Department of Internal Medicine, Dr. Moewardi Hospital Surakarta

 

ABSTRACT

Background: Tuberculosis (TB) remains a major infectious disease globally. Treatment of latent tuberculosis infection (LTBI) focuses on preventing active TB. Treatment of LTBI is recommended for high-risk population such as patients with diabetes mel- litus (DM). DM is a noncommunicable disease that can impair immunity and lead to increased susceptibility to various infectious diseases including TB. Previous studies stated that TSPOT.TB and tuberculin skin test (TST) are recomended for diagnosis of LTBI. This study aimed to investigate the agreement, sensitivity, and specificity of TST and T-SPOT TB examination, in detecting LTBI among patients with DM.

Subjects and Method: This was a cross sectional study conducted at Dr Moewardi Hospital Surakarta, Central Java, in September 2018. A total 30 patients with DM was selected for this study. The dependent variables were (1) Kappa agreement; (2) Sensitivity; and (3) Specificity. The screening tests under study were T-SPOT TB and TST. Results: The prevalence of LTBI was 20% among patients with DM. The TST had moderate agreement with T-SPOT TB (Kappa= 0.66; p<0.001). T-SPOT.TB (23.8%) had higher sensitivity than TST (14.3%). However, TST (100%) had higher specificity than T-SPOT.TB (88.9%).

Conclusion: The TST has moderate agreement with T-SPOT TB among patients with DM. T-SPOT.TB had higher sensitivity than TST. However, TST had higher specificity than T-SPOT.TB.

Keywords: LTBI, TST, T-SPOT.TB, HbA1c, diabetes mellitus.

Correspondence: Nur Amalia Santang. Department of Pulmonology and Respiratory Medicine, Dr. Moewardi Hospital Surakarta, Jl. Kolonel Soetarto No. 132 Surakarta, Central Java. Email: amaliasantang@gmail.com. Mobile: 0813 2877 4833.

DOI: https://doi.org/10.26911/the6thicph.01.59

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