Effect of Umbilical Cord Clamping Time on Placental Redistribution and Anemia in Infants: A Systematic Review

Lukyta Pratika Dewi, Esitra Herfanda


Universitas Aisyiyah Yogyakarta



Background: Iron deficiency anemia develops when body stores of iron drop too low to support normal red blood cell (RBC) production. Infants are born with iron stored in their bodies. Iron deficiency anemia most commonly affects babies 9 through 24 months old. World Health Organization (WHO) reported that delaying cord clamping allows blood flow between the placenta and neonate to continue, which may improve iron status in the infant for up to six months after birth. This study aimed to systematically review the effect of umbilical cord clamping time on placental redistribution and anemia in infants.

Subjects and Method: A systematic review was conducted by searching articles from PubMed, ProQuest, and Scanning direct databases, during 2011-2018. The keywords were ―cord clamping, ―infant, ―anemia, and ―placenta. The articles were reviewed by PRISMA flow diagram. Seven articles of 1087 articles were identified and reviewed in this study.

Results: Studies reported that infants who had delayed umbilical cord clamping had significantly less impact of residual placenta blood volume (RPBV). In addition, it had a significantly higher increase in hemoglobin level, as well as serum ferritin, with a lower relative risk (RR) for anemia of 0.91 than infants undergoing early cord clamping.

Conclusion: The time of umbilical cord clamping is very influential on placental redistribution and anemia in infants. The application of the time of umbilical cord clamping delay in infants is beneficial in increasing red blood cell mass and improving iron status as an alternative to preventing iron deficiency anemia in infants.

Keywords: cord clamping, infants, anemia, placenta

Correspondence: Lukyta Pratika Dewi. Universitas Aisyiyah Yogyakarta. Jl. Ringroad Barat No.63, Mlangi, Nogotirto, Gamping, Sleman, Yogyakarta, Indonesia. Email: kylucky24@gmail.com. Mobile: 082140378324.

DOI: https://doi.org/10.26911/the6thicph.03.63

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