Patient Characteristics with The Drugs Provocation Test in Sanglah Hospital from 2017 to 2018

I Kadek Adi Paramartha1), I Ketut Suardamana2,3)


1)Ari Canti General Hospital, Gianyar, Bali

2)Division of Allergy Immunology, Internal Medicine Department, Sanglah Hospital

3)Faculty of Health Medicine, Universitas Udayana



Background: Drug provocation test (DPT) is one of the diagnostic modalities to determine drugs that are suspected of triggering drug adverse reactions, especially allergic reaction. The aim of the study was to review the characteristics and results of patients undergoing DPT at Sanglah General Hospital, Bali.

Methods: This was a retrospective study conducted at Sanglah General Hospital, Bali from 2017 to 2018. A total of 20 patients with 53 provocation tests carried out with different drugs were enrolled in this study. The data were obtained from medical record. The data were analyzed descriptively.

Results: Out of the 20 patients, 53 provocation tests were carried out, most patients were women (55%) with an average age of 48.35 years. Positive results were 46 (86.8%) and negative were 7 (13.2%) patients. Patients with the most diagnosis of pulmonary tuberculosis underwent DPT (35%). Ethambutol was the drug most frequently tested for drug provocation tests (18.9%).

Conclusion: This study describes the patients experience of hypersensitivity reactions undergoing DPT. DPT is still useful as a gold standard in diagnosing hypersensitivity reactions, especially in patients who are given drugs with a high risk of hypersensitivity reactions.

Keywords: drug provocation test, hypersensitivity reaction, allergy

Correspondence: I Kadek Adi Paramartha. Ari Canti General Hospital, Gianyar, Bali. Jl. Raya Mas Ubud No.88x Gianyar, Bali. Email: Mobile: 081353774767


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