Incomplete Medication Intake and Multidrug Resistant Tuberculosis

Widya Kurnianingsih1), Didik Gunawan Tamtomo2), Bhisma Murti3)


1)Masters Program in Public Health, Universitas Sebelas Maret

2)Faculty of Medicine, Universitas Sebelas Maret



Background: Multidrug Resistant Tuberculosis (MDR-TB) is a highest problem in the prevention and eradication of TB worldwide. MDR-TB exists in 27 countries where there are at least 6,800 MDR-TB cases annually and 12% of new TB cases registered are MDR TB. This study aimed to examine the effect of incomplete medication intake on the incidence of MDR TB.

Subjects and Method: Meta-analysis and systematic review was conducted by collecting articles from Google Scholar, Pubmed, and Springer Link databases, from year 2010 to 2019. Keywords used “Risk Factor MDR TB” OR “Previous Treatment” AND “Multidrug resistant tuberculosis”. The inclusion criteria were full text, using English language, using case control study design, and reporting adjusted odds ratio. The study population was patients with Tuberculosis. The intervention was incomplete medication intake with comparison complete medication intake. The study outcome was multidrug resistant Tuberculosis. Collected articles were selected by PRISMA flow chart. Quantitative data were analyzed by fixed effect model using Revman 5.3.

Results: 6 studies from Taiwan, Bangladesh, Malaysia, and Ethiophia were selected for data analysis. This study reported that incomplete medication intake increased the risk of multidrug resistant tuberculosis (aOR= 14.33; 95% CI= 12.47 to 16.47; p<0.001).

Conclusion: Incomplete medication intake increases the risk of multidrug resistant Tuberculosis.

Keywords: incomplete medication intake, multidrug resistant tuberculosis

Correspondence: Widya Kurnianingsih. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 081556837033.


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