Meta-Analysis: Effect of Exposure to Rodent on the Risk of Leprosy in Adults

Rizki Kurniawan Saputra1), Setyo Sri Rahardjo2), Bhisma Murti1)


1)Masters Program in Public Health, Universitas Sebelas Maret

2)Faculty of Medicine, Universitas Sebelas Maret



Background: Leprosy is caused by Mycobacterium leprae. The mechanism of transmission of leprosy consists of prolonged close contact between susceptible and genetically predisposed individuals and untreated multi-bacillary patients. The purpose of this study was to examine effect of exposure to rodent on the risk of leprosy in adults.

Subjects and Method: This was meta-analysis and systematic review. The study collected articles from Google Scholar, PubMed, and Science Direct databases, which published from year 2000 to 2020. Keywords used “risk factors” OR “Leprosy” AND “rodent exposure” AND “case control”. The study subject was adults aged 26-65 years. The intervention was rodent exposure with comparison without rodent exposure. The study outcome was Leprosy. Collected articles were filtered using PRISMA flow chart. The quantitative data were analyzed by Revman 5.3.

Results: 6 studies from Brazil, Laos, Jamaica, India, Mexico, and Nicaragua were met the inclusion criteria. This study reported that exposure to rodent increased the risk of leprosy in adults (aOR= 2.32; 95% CI= 1.37 to 3.95; p= 0.002).

Conclusion: Exposure to rodent increases the risk of leprosy in adults.

Keywords: Leprosy, rodent, meta-analysis

Correspondence: Rizki Kurniawan Saputra. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 0877 3815 2955.


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