Meta-Anaylsis: Gender and the Risk of Lower Extremity Amputation in Patients with Type 2 Diabetes Mellitus and Foot Ulcer

Anissa Eka Septiani1), Bhisma Murti1), Setyo Sri Rahardjo2), Hanung Prasetya3)


1)Masters Program in Public Health, Universitas Sebelas Maret

2)Faculty of Medicine, Universitas Sebelas Maret

3)Study Program of Acupuncture, School of Health Polytechnics,

Ministry of Health, Surakarta



Background: Diabetes is an independent predictor of limb amputation (versus revascularization) for the treatment of critical limb ischemia. Much of the cost related to diabetes results from macrovascular and microvascular complications, such as myocardial infarctions, end-stage renal disease, and lower extremity amputations (LEAs). This study aimed to examine the associations between gender and the risk of lower extremity amputation in patients with type 2 diabetes mellitus and foot ulcer.

Subjects and Method: A meta-analysis and systematic review was conducted by collected published articles from Pubmed, Scopus, Google Scholar, and Springer Link databases. Lower limb amputation, lower extremity amputation, diabetic foot, and diabetic ulcer keywords were used to collect the articles. The inclusion criteria were full text, cohort study, and reporting adjusted odds ratio. The selected articles were analyzed by PRISMA flow chart and revman 5.3.

Results: 9 articles were reported that male increased the risk of lower extremity amputation in type 2 DM patients (aOR= 1.60; 95% CI= 1.32 to 1.94; p<0.001).

Conclusion: Male increases the risk of lower extremity amputation in type 2 DM patients.

Keywords: lower extremity amputation, type 2 diabetes mellitus, foot ulcer

Correspondence: Anissa Eka Septiani. Masters Program in Public Heath, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: Mobile: 089514646458.


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