The Effect of Depression Comorbidity on the Quality of Life of Patients with Type 2 Diabetes Mellitus: Meta-Analysis

Rofana Aghniya1), Bhisma Murti1), Didik Gunawan Tamtomo1)Hanung Prasetya2)


1)Masters Program in Public Health, Universitas Sebelas Maret

2)Study Program of Acupuncture, School of Health Polytechnics, Ministry of Health, Surakarta



Background: The prevalence of depression is two to three times higher in diabetic patients, while most cases remain undiagnosed. The quality of life is substantially and adversely affected by depression. This study aimed to estimate the effect of depression comorbidity on patients’ quality of life with type 2 diabetes mellitus.

Subjects and Method: This was a meta-analysis and systematic review. The study was conducted by collecting published articles from PubMed, ProQuest, Science Direct, Scopus, Spinger Link, Clinical Key, and Google Scholar databases. Keywords used “comorbidity depression and DM”, “depression and quality of life and DM and cross sectional study”, “depression and quality of life and DM and adjusted odd ratio”, “depression or diabetes”, “depression or quality of life or DM or adjusted odd ratio”. The study criteria were full text, using cross-sectional study design, and reporting adjusted Odds Ratio (aOR). The selected articles were analyzed using Revman 5.3 with fixed effect models.

Results: 8 studies from Uganda, Iran, United States, United Kingdom, Australia, Nigeria, Brazil, and Nepal, were selected for this study. Current study reported that type 2 DM patients with depression had lower quality of life than those without depression (aOR= 2.72; 95% CI= 0.73 to 10.07; p<0.0001)

Conclusion: Type 2 DM patient with depression has lower quality of life than those without depression.

Keywords: depression, quality of life, diabetes mellitus

Correspondence: Rofana Aghniya. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: +685523528340.


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