Effect of Obesity and Family History on the Risk of Breast Cancer: Meta Analysis

Enge Surabina Ketaren1), Bhisma Murti1), Vitri widyaningsih2)


1)Masters Progamin Public Health, Universitas Sebelas Maret
2)Faculty of Medicine, Universitas Sebelas Maret



Background: Breast cancer is the most common cancer among women worldwide and currently ranked as the fifth leading cause of death from cancer in general. Studies have indicated that breast cancer was strongly associated with a positive family history of breast cancer.The risk of breast cancer also increased with the increasing levels of body‐mass index. This study aimed to examine the effect of obesity and family history on the risk of breast cancer.

Subjects and Method: Meta analysis and systematic review was conducted by collecting published articles from Google Scholar, PubMed, Springer Link, DOAJ, and Science Direct databases.Keywords used “breast cancer” AND “risk factors” AND “BMI” OR “body mass index” AND “obesity”AND “family history” AND “cohort” AND “Asia”. The inclusion criteria were full text, using English language, using cohort study design, and reporting adjusted hazard ratio.The study population was Asian women. Intervention was obesity and family history with comparison non-obesity and no family history. The study outcome was breast cancer. The collected articles were selected by PRISMA flow chart. The quantitative data were analyzed by random effect model using Revman 5.3.

Results: 6 studies fromTaiwan, Israel, Japan, Malaysia, Thailand, and Korea were selected for this study. This study showed that obesity (aHR= 1.01; 95% CI= 0.67 to 1.52; p= 0.96), with I²= 90% and family history (aHR= 1.69; 95% CI= 1.09 to 2.62; p= 0.02), with I²= 57%, were associated with breast cancer.

Conclusion: Obesity and family history are associated with breast cancer.

Keywords: breast cancer, obesity, family history

Correspondence: Enge Surabina Ketaren. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ketarenenge3@gmail.com. Mobile: 087838583646.

DOI: https://doi.org/10.26911/the7thicph.05.56

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