Effect of Obstructive Sleep Apnea on Incidence of Pre-eclampsy in Pregnant Women: A Systematic Review


Sulis Diana1,2), Chatarina Umbul Wahyuni3), Budi Prasetyo4)

 

1)School of Health Sciences Majapahit Mojokerto
2)Doctoral Program, Faculty of Public Health, Universitas Airlangga, Surabaya
3)Epidemiology Department, Faculty of Public Health, Universitas Airlangga, Surabaya
4)Department Obstetri Gynecology Medical Faculty, Universitas Airlangga, Soetomo general academic hospital

 

ABSTRACT

Background: The prevalence of preeclampsia is around 5-8% of all diseases that occur during pregnancy. There was an increase from 10.5% of women with OSA in the first trimester to 26.7% in the third trimester. This study aimed to investigate the effect of obstructive sleep apnea on incidence of preeclampsia in pregnant women.

Subjects and Method: A systematic review was conducted by searching the articles from PubMed and Google Scholar databases published between 2015 to 2019. An obstructive sleep apnoea (OSA) analysis was performed. Sensitivity analysis was performed to identify designs, summary results and publication estimates.

Results: As many as 15 studies with a total of 1,837 subjects were included. OSA during pregnancy was associated with an increased risk of preeclampsia. The selected studies were conducted in observational designs. The existing studies showed that maternal OSA was significantly associated with preeclampsia (aOR= 1.96; 95% CI= 1.30 to 2.42).

Conclusion: There is the adverse relationship of OSA and preeclampsia. OSA increases the risk of multiple pregnancy and perinatal complications.

Keywords: preeclampsia, OSA, pregnancy

Correspondence: Sulis Diana. Doctoral Program, Faculty of Public Health, Universitas Airlangga, Surabaya, East Java. Email: Diana.sulis6@gmail.com. Mobile: +6282234209942.

DOI: https://doi.org/10.26911/the7thicph.03.82

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