Effect of Thymoquinone on Interleukin-8, FEV1, and COPD Assessment Test Score in Stable Chronic Obstructive Lung Disease


Yusup Subagio Sutanto, Levana Kasumadewi, Suradi, Ana Rima Setijadi, Hendra Kurniawan

 

Department of Pulmonology and Respiratory Medicine, Universitas Sebelas Maret Dr. Moewardi Hospital, Surakarta

 

ABSTRACT

Background: Chronic obstructive pulmonary disease (COPD), a persistent airway obstruction, is  caused  by  continuous  exposure  to  harmful  particles  or  irritants.  Airway  inflammation contributes the pathogenesis of COPD. Thymoquinone, has an anti-inflammatory effect. This study aimed to examine the effect of thymoquinone on interleukin-8 (IL-8) level, percentage of FEV1, and COPD assessment test score (CAT) in stable chronic obstructive lung disease.

Subjects  and  Method:  A  quasi-experiment  with  pretest  and  posttest  control  group  was conducted at the outpatient pulmonology unit, Dr. Moewardi, Surakarta, Central Java, from June to August 2019. A sample of 40 patients diagnosed with stable COPD was selected and allocated into two groups: (1) 20 patients treated with a combination of standard therapy and thymoquinone oil capsules 500 mg/ day; and (2) 20 patients treated with standard therapy. The dependent variables  were  IL-8  level,  FEV1,  and  COPD  assessment  test  score  (CAT). The  independent variables were treatment status. The data were analyzed by the paired-t-test.

Results: The level of IL-8 was lower after treatment with combination of standard therapy and thymoquinone oil capsules 500 mg/ day (Mean= 14.35; SD= 3.95) than before treatment (Mean= 19.62; SD= 12.14), and it was not statistically significant (p= 0.052). The percentage of FEV1 was lower after treatment with combination of standard therapy and thymoquinone oil capsules 500 mg/ day (Mean= 42.36; SD= 14.43) than before treatment (Mean= 42.56; SD= 16.09), and it was not statistically significant (p= 0.943). The CAT score was lower after treatment with combination of standard therapy and thymoquinone oil capsules 500 mg/ day (Mean= 13.70; SD= 4.24) than before treatment (Mean= 13.70; SD= 4.24) than before treatment (Mean= 18.65; SD= 5.92), and it was statistically significant.

Conclusion: Chronic obstructive pulmonary disease assessment test (CAT) score significantly decreases with the treatment combination of standard COPD therapy and thymoquinone oil capsules 500 mg/ day.

Keywords: Thymoquinone, stable COPD, IL-8, FEV1, CAT score

Correspondence: Yusup Subagio Sutanto. Department of Pulmonology and Respiratory Medicine, Dr. Moewardi Hospital Surakarta. Jl. Kolonel Soetarto No. 132 Surakarta, Central Java. Email: dr_yusupsubagio@yahoo.com. Mobile: +62811284165.

DOI: https://doi.org/10.26911/the7thicph.05.34

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