Meta-Analysis of the Effect of Probiotics on the Duration of Diarrhea in Children Under Five

Wahyu Agustin Dwi Ciptaningtyas1), Bhisma Murti1), Setyo Sri Rahardjo2)


1)Masters Program in Public Health, Universitas Sebelas Maret
2)Faculty of Medicine, Universitas Sebelas Maret



Background: Diarrhea is a common problem for children under five years of age. Multiple diarrhea episodes can lead to serious problems such as childhood malnutrition in developing or non-industrialized countries. In Indonesia, 70-80% of 60 million people who suffer diarrhea are children under five years of age. Apart from the existing treatment guidelines for diarrhea, probiotic or non-pathogenic living microorganisms are supposed to have preventive and curative effects on many diarrhea forms. This study aimed to estimate the effect of probiotics on the frequency and duration of diarrhea in children under five years of age.

Subjects and Method: This was meta-analysis and systematic review.This study collected articles which published year 2010-2020. The articles were obtained from PubMed, Science Direct, Research Gate, and Google Scholar databases. The inclusion criteria were full text, using randomized controlled trial (RCT) study design, using probiotics intervention, the study subjects was children under five with diarrhea, and reporting effect size value (mean and standard deviation). The selected articles were analyzed using Revman 5.3.

Results: There were 5 articles reviewed for this study. There was high heterogeneity between experimental groups(I2= 89%; p= 0.09). Probiotics provision were effectively to shortened duration of diarrhea 0.39 times than without probiotics provision (Mean Difference= -0.39; 95% CI= 0.85 to -0.07; p= 0.090).

Conclusion: Probiotics are effective to shortened duration of diarrhea in children under five.

Keywords: probiotic, diarrhea, meta-analysis

Correspondence: Wahyu Agustin Dwi Ciptaningtyas. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java.Email: Mobile : 082229991202.


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