Meta Analysis: The Effect of Type 2 Diabetes Mellitus in Stroke

Dody Suprayogi1), Agus Kristiyanto2), Hanung Prasetya3)


1)Masters Program in Public Health, Universitas Sebelas Maret
2)Faculty of Teaching and Educational Sciences, Universitas Sebelas Maret
3)Study Program in Acupuncture, Health Polytechnics, Ministry of Health, Surakarta



Background: Diabetes can cause pathologic changes in blood vessels at various locations and can lead to stroke if cerebral vessels are directly affected. Additionally, mortality is higher and poststroke outcomes are poorer in patients with stroke with uncontrolled glucose levels. The purpose of this study was to examine the effect of type 2 diabetes mellitus in stroke.

Subjects and Method: Meta analysis and systematic review was conducted by collecting published articles from PubMed, Science Direct, Google Sscholar, Mendeley, and Clinical key databases. Keywords used “Diabetes Mellitus” AND “Type 2 Diabetes Mellitus” AND “Stroke” AND “Risk Factor of Stroke” AND “Cross-sectional”. The inclusion criteria were full text and using cross-sectional study design. The articles were collected and selected by PRISMA flow chart. The quantitative data were analyzed by Review Manager 5.3.

Results: Meta analysis from 6 studies reported that type 2 DM increased the risk of stroke (aOR= 1.90; 95% CI= 1.41 to 2.57; p<0.001) with heterogeneity (I2= 78%).

Conclusion: Type 2 DM increases the risk of stroke.

Keywords: type 2 diabetes mellitus, stroke

Correspondence: Dody Suprayogi. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 08562772052.


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