Obesity and Gastroesophageal Reflux Disease: A Meta-Analysis Study in Asia and America

Alfiani Vivi Sutanto1), Pawito2), Hanung Prasetya3)


1)Masters Program in Public Health, Universitas Sebelas Maret
2)Faculty of Social Science and Politics, Universitas Sebelas Maret
3)Study Program of Acupunture, Health Polytechnics, Ministry of Health, Surakarta



Background: Gastroesophageal reflux disease (GERD) is a common disorder with a prevalence of 20% in the United States and less than 5% in Asia. Untreated, GERD can result in a symptomatic burden to the patient, poor health-related quality of life, complications, such as esophageal stricture, Barrett’s esophagus, and esophageal adenocarcinoma, and a high direct and indirect cost to the healthcare system. Various pathophysiological mechanisms have been identified to explain the relationship between obesity and GERD, including a high prevalence of hiatal hernia and increased gastroesophageal pressure gradient. This study aimed to examine the association between obesity and GERD in Asia and America.

Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting articles from PubMed, Google Scholar, BMC Journals, Science Direct, Mendeley, and clinical key databases. Keywords used “Obesity” OR “HMI” AND “Gastroesophageal reflux disease” OR “GERD” AND “Effect obesity for GERD” AND “aOR”. The inclusion criteria were full text, using cross-sectional study design, and reporting adjusted odds ratio. The study population was adults who experienced GERD. Intervention was obesity. The study outcome was gastroesophageal reflux disease (GERD). The articles were selected using PRISMA flow chart. The quantitative data were analyzed using random effect model run on Revman 5.3.

Results: 5 studies were analyzed and reviewed for this study. Current study reported that obesity increased the risk of gastroesophageal reflux disease (GERD) (aOR= 2.04; 95% CI=1.42 to 2.92; p= 0.001).

Conclusion: Obesity increases the risk of gastroesophageal reflux disease.

Keywords: obesity, gastroesophageal reflux disease

Correspondence: Alfiani Vivi Sutanto. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: alfianivivi85@gmail.com. Mobile: 085799253568.

DOI: https://doi.org/10.26911/the7thicph.05.50

Share this :

View PDF