The Effects of Ferric Carboxymaltose Versus Iron Sucrose on the Ferritin Level in Pregnant Women with Anemia: A Meta-Analysis

Astika Candra Nirwana1), Yulia Lanti Retno Dewi2), Bhisma Murti1)


1)Masters Program in Public Health, Universitas Sebelas Maret
2)Faculty of Medicine, Universitas Sebelas Maret



Background: Prophylactic oral iron is recommended during pregnancy to meet the increased requirement during the antenatal period. The most commonly used iron preparation for anemia in pregnancy is iron sucrose complex (ISC). The purpose of this study was to compare the effects of ferric carboxymaltose versus iron sucrose on the ferritin level in pregnant women with anemia.

Subjects and Method: This was a meta-analysis study. The study was conducted by collecting published articles from 2010 to 2019 in PubMed, Science Direct, and Google Scholar databases. The keywords used to search the articles including “Ferric Carboxymaltose”, “Ferric Carboxymaltose and anemia in pregnancy”, and “the effect of Ferric Carboxymaltose for anemia”. The inclusion criteria was full text with randomized control trial study, anemia therapy provision using ferric carboxymaltose versus iron sucrose, and the study subjects were pregnant women with anemia. The selected articles were analyzed using Revman 5.3.

Results: 5 articles that meet the inclusion criteria were selected for this study. There was high heterogeneity between experiment group (I2 = 96%; p= 0.020). Therefore, this study used random effect model. Ferric carboxymaltose provision increased feritin level 0.89 times than iron sucrose (Mean Difference= 0.89; 95% CI= 0.12 to 1.66; p<0.001).

Conclusion: Ferric carboxymaltose is effective to increased feritin level in pregnant women.

Keywords: ferric carboxymaltose, iron sucrose, randomized controlled trial

Correspondence: Astika Candra Nirwana. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 085640018896


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