Relative Efficacy of Probiotics Compared with Standard Therapy for Diarrhea Treatment in Children Under Five Years of Age: A Meta-Analysis Evidence from Developing Countries

Nurul Aini Suria Saputri1,2), Tri Nugraha Susilawati3), Vitri Widyaningsih3)



1)Midwifery Department, School of Health Polytechnics, Tanjungpinang

2)Masters Program in Public Health, Universitas Sebelas Maret

3)Faculty of Medicine, Universitas Sebelas Maret


Background: Probiotics have been widely studied in a variety of gastrointestinal diseases. There is high-quality evidence that probiotics are effective for acute infectious diarrhea. This study aimed to examine the relative efficacy of probiotics compared with standard therapy for diarrhea treatment in children under five using meta-analysis.
Subjects and Method: A meta-analysis was carried out using systematic PRISMA guidelines. The review process begins with searching for articles published between 2009 and 2019 from PubMed, Clinical Key, ScienceDirect, and Scopus databases. This study obtained four articles that meet the criteria of the randomized controlled trial (RCT), the study subjects were toddlers and conducted in developing countries. A sample of 995 children was divided into two groups, 518 children received probiotics (intervention) and 477 children received standard therapy (control). The data were analyzed by Review Manager (RevMan) software 5.3 to assess Standardized Mean Difference (SMD).
Results: Probiotics administration reduced duration of acute diarrhea in children under five than standard therapy, with pooled estimate= 0.30 (SMD= -0.30; 95% CI= – 0.56 to -0.03).
Conclusion: Probiotics administration combined with standard therapy is effective to reduce the duration of acute diarrhea in children under five in developing countries.
Keywords: acute diarrhea, probiotic, children under five
Correspondence:Nurul Aini Suria Saputri. Midwifery Department, School of Health Polytechnics, Tanjungpinang/ Masters Program in Public Health, Universitas Sebelas Maret. Jl. Arief Rahman Hakim No.1, Tanjungpinang, Riau Islands. Email: Mobile: +6285743401971.


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