The Effect of Vitamin D Supplementation on The Pre-Eclampsia Risk Reduction in Pregnant Women: A Meta-Analysis

Fanny Kartika1), Bhisma Murti2), Eti Poncorini Pamungkasari3)


1)Masters Program in Public Health, Universitas Sebelas Maret

2)Faculty of Medicine, Universitas Sebelas Maret



Background: Pre-eclampsia (PE), a complication of pregnancy, remains a major cause of maternal and fetal morbidity and mortality. Research showed that vitamin D reduces the risk of pre-eclampsia in pregnant women. The recommended dose for vitamin D supplementation is 600 IU per day. This study aimed to determine the effect of vitamin D supplementationon the pre-eclampsia risk reduction in pregnant women.

Subjects and Method: This was a meta-analysis and sytematic review toward vitamin supplementation and pre-eclampsia in pregnant women. Published original studies from PubMed, Science Direct, Springer Link, and Google Scholar databases, from year 2013 to 2017 were collected for this study. Keywords used “Vitamin D” AND “Decrease Risk” OR “Prevention” OR “Reduce Risk” AND “Pre-eclampsia”. The inclusion criteria were full text, in English language, using randomized controlled trial study design, and reporting odds ratio. The selected articles were analyzed using PRISMA guideline and Revman 5.3.

Results: 7 studies were met inclusion criteria. This study showed that vitamin D supplementation reduced the risk of pre-eclampsia in pregnant women (OR= 0.97; 95% CI= 0.79 to 1.18; p=0.730), with (I2 = 86%; p<0.001).

Conslusion: Vitamin D supplementation reduces the risk of pre-eclampsia in pregnant women.

Keywords: vitamin D supplementation, pre-eclampsia

Correspondence: Fanny Kartika Fajriyani. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 085728125412.


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