Effect of Obesity on Polycystic Ovary Syndrome: Meta-Analysis

Saktryana Endang Ragil Jayanti, Bhisma Murti


Masters Program in Public Health, Universitas Sebelas Maret




Background: Polycystic ovary syndrome (PCOS) is the most common hormonal abnormality in reproductive-age women. The reproductive features of PCOS include increased androgen production and disordered gonadotropin secretion leading to menstrual irregularity, hirsutism, and infertility. Obesity is a common finding in women with PCOS and between 40–80% of women with this condition are reported to be overweight or obese. The purpose of this study was to explore the effect of obesity on polycystic ovary syndrome.

Subjects and Method: This was a systematic review and meta-analysis was conducted by PRISMA flow diagram. The articles were collected from PubMed, Science Direct, and Google Scholar databases. Research problems were formulated in PICO, as follows: (1) Population= women, (2) Intervention= polycystic ovary syndrome, (3) Comparison= normal, and (4) Outcome= obesity. Keywords used obesity AND PCOS OR BMI AND PCOS AND “logistic regression”. The inclusion criteria were full text, articles were published from year 2015 to 2020, case control study, and reported adjusted Odds Ratio. Articles that met the criteria were analyzed by Revman 5.3.

Results: A meta analysis involved 6 primary studies from United States, Brazil, China, Central China, Iraq, and Pakistan. This study reported that there was no significant correlation between obesity polycystic ovary syndrome (aOR= 1.04; 95% CI= 0.78 to 1.40; p= 0.790).

Conclusion: There is no significant correlation between obesity polycystic ovary syndrome.

Keywords: obesity, body mass index, polycystic ovary syndrome

Correspondence: Saktryana Endang Ragil Jayanti. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: saktryana.agil@gmail.com. Mobile: 082242154117.

DOI: https://doi.org/10.26911/AB.Maternal.ICPH.08.2021.28

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