The Effect of Hiv Status on the Medication Failure in Tuberculosis Patients: A Meta Analysis

Riski Anisa

Masters Program in Public Health, Universitas Sebelas Maret


Background: HIV and Tuberculosis (TB) interact synergistically, speeding the progression of illness and increasing the likelihood of death. The presence of HIV enhances the reactivation and progression of latent M. tuberculosis to overt TB disease, and having TB disease accelerates HIV disease progression. It also alters the clinical presentation of TB and complicates the treatment follow-up. Therefore to reduce the burden of HIV in TB patients, HIV testing and acting upon one’s HIV status is mandatory. For this reason a TB clinic can be an extremely important entry point for HIV prevention, care and treatment. This study aimed to

Subjects and Method: A systematic literature search was conducted in multiple databases including PubMed, Science Direct, Google Scholar, to identify studies published from 2016 to 2021. The following search terms were used: “HIV status” AND “Unseccessful TB Treatment” AND “TB patients” AND “Cohort”. The articles were filtered using PICO model, including: (1) Population= Tuberculosis patients, (2) intervention= positive HIV status, (3) compa­rison= negative HIV status, and (4) outcome= Tuberculosis treatment failure. The inclu­sion criteria were English or Indonesian full-text, cohort study, and reported adjusted odds ratio (aOR). The study instrument for assessing smoking cessation was Fagerstrom test for nicotine dependence. The systematic review was carried out according to the PRISMA guide­lines. Data analysis were performed using RevMan 5.3.

Results: There were 5 studies from Malaysia, Ethiopia, Thailand, Nigeria, and Papua New Guinea that met the eligible criteria for meta-analysis. This study reported that HIV-positive status elevated the risk of TB treatment failure (aOR= 2.20; 97% CI= 1.17 to 4.17; p= 0.010).

Conclusion:  HIV-positive status elevates the risk of TB treatment failure.

Keywords: HIV status, TB treatment failure

Correspondence: Riski Anisa. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 51726, Central Java. Email: Mobile: +62857­49027212.


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