Effect of Anticoagulant Drugs in Reducing the Risk of Mortality In COVID-19 Patients: A Meta-Analysis

Happy Nurhayati


Masters Program in Public Health, Universitas Sebelas Maret



Background: covid-19 is widely continue to spread worldwide. Deaths among people with covid-19 have been partially attributed to venous throm­boembolism and arterial thromboses. Several expert organizations have recommended prophylactic anticoagulation for patients admitted with covid-19, who do not have a contraindication to this treatment, to reduce the risk of thromboembolism. However, results from different studies comparing the effect of anticoagulation on the mortality of COVID-19 patients with non-anticoagulation are inconclusive. A systematic review and meta-analysis was conducted to assess the effect of anticoagulant drugs in reducing the risk of mortality in covid-19 patients.

Subjects and Method: A systematic review was conducted using the Pub¬Med, Science direct, Scopus databases, published from 2020 to 2021. Eligibility criteria were defined using the PICO model as follows, (1) population: COVID-19 patients, (2) intervention: coagulant drugs, (3) comparison: non-coagulant drugs, and (4) outcome: mortality. The following search terms were used: “anticoagulant” AND “mortality” AND “COVID-19”. The inclusion criteria were English full-text, cohort retrospective study, and reported adjusted Odds Ratio (aOR). Data analyses were performed using REVMAN 5.3.

Results: Six studies were selected from Kuwait, German, Italy, China, and Spain. This study showed that coagulant drugs reduced the risk of mortality in COVID-19 patients, but it was statistically non-significant (OR= 0.51; 95% CI= 0.39 to 0.66; p= 0.160).

Conclusion: Coagulant drugs reduces the risk of mortality in COVID-19 patients.

Keywords: Anticoagulant, mortality, COVID-19

CorrespondenceHappy Nurhayati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: happynurhayati­@­stu­de­nt­.­uns.ac.id. Mobile: +62812-2616-0538.

DOI: https://doi.org/10.26911/AB.Medicine.ICPH.08.2021.16

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