Outcome of Parenteral Nutrition on Low Birth Weight

Muthia Syafira1,2), Rasmaya Niruri1), Wahyu Sedjatiningsih3)

1)Masters Program in Public Health, Universitas Sebelas Maret

2)Study Program in Pharmacy, Universitas Sebelas Maret

3)Pharmacy Installation, Dr. Moewardi  Hospital, Surakarta



Background: Infants born prematurely often fail to grow at rates similar to those estimated for the in-utero fetus. Protein and energy deficits during postnatally were directly related to subsequent postnatal growth restriction. Several studies demonstrated that early parenteral nutrition provided benefit for short-term outcomes without evidence of increased morbidity and mortality. This study aimed to investigate outcome of parenteral nutrition on low birth weight.

Subjects and Methods: A cross sectional study was carried out from February to June 2020. A number of 71 LBW infants was selected for this study. The dependent variable was infant weight and mortality. The independent variables were comorbidity, formula milk, length of formula milk consumption, and length of parenteral intake. The data were obtained from medical record and questionnaire. The data were analyzed using a multiple logistic regression.

Results: The risk or mortality in LBW infants increased with formula milk consumption (OR= 38.16; 95% CI= 8.16 to 178.54; p<0.001) and presence of comorbidity (OR= 5.72; 95% CI= 1.34 to 24.44; p= 0.019). Infant weight gain increased with length of formula milk consumption (OR= 3.29; 95% CI= 1.10 to 10.62; p= 0.041). It decreased with short length of parenteral intake (OR= 0.20; 95% CI= 0.06 to 0.63; p= 0.006).

Conclusion: The risk or mortality in LBW infants increases with formula milk consumption and presence of comorbidity. Infant weight gain increases with length of formula milk consumption but decreases with short length of parenteral intake.

Keywords: low birth weigth, parenteral nutrition, mortality, nutritional status

Correspondence: Muthia Syafira. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: mutsyaf@student.uns.ac.id. Mobile: 085920660180.


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