Effects of Delayed Treatment, Arthralgia, and Anemia, on the Cure and Survival in Patients with Multi Drug-Resistant Tuberculosis


Linda Soebroto, Reviono, Yusup Subagio Sutanto

 

Department of Pulmonology and Respiratory Medicine,

Faculty of Medicine, Universitas Sebelas Maret, Surakarta

 

ABSTRACT

Background: Multidrug-resistant tuberculosis had high treatment failure and morta­lity. Success rate of treatment currently 56% at global level and 48% in Indonesia. This study aimed to determine the effects of delayed treatment, arthralgia, and anemia, on the cure and survival in patients with multi drug-resistant tuberculosis.

Subjects and Method: This was a retrospective cohort study conducted at Dr. Moe­wardi Hospital, Surakarta, Central Java, from January 2015 to August 2020. A sample of 372 drug resistant tuberculosis patients who underwent treatment were selected for the study. The dependent variables were treatment failure (inverse of cure) and morta­lity (inverse of survival). The independent variables were delayed treatment, arthralgia, and anemia. The drug resistant tuberculosis patient data were obtained from the medi­cal record. The data were analyzed using Cox proportional hazard model.

Results: Delayed treatment (HR= 2.91; 95%CI= 1.89 to 4.47; p=<0.001) and arthral­gia (HR= 1.77, 95%CI=1.15 to 2.74; p=0.010) were associated with an increased chance of treatment failure. Delayed treatment (HR= 14.77; 95%CI= 13.38 to 16.16; p<0.001), arthralgia (HR= 15.17; 95%CI= 13.96 to 16.39; p<0.001), and anemia (HR= 15.30; 95% CI= 14.07 to 16.53; p=0.002) were associated with an increased chance of mortality.

Conclusion: Delayed treatment, arthralgia, and anemia are associated with increased chance of treatment failure and mortality.

Keywords: delayed treatment, arthralgia, anemia, treatment failure, mortality, drug-resistant tuberculosis

Correspondence: Linda Soebroto. Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: soebrotolinda@hotmail.com. Mobile: 081332335559

DOI: https://doi.org/10.26911/AB.Medicine.ICPH.08.2021.43

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