Combination Oral Contraceptive on The Risk of Venous Thromboemboli: A Meta-Analysis

Putri Yunita Sari1), Eti Poncorini Pamungkasari2), Bhisma Murti1)


1)Masters Program in Public Health, Universitas Sebelas Maret

2)Faculty of Medicine, Universitas Sebelas Maret



Background: Drospirenone-containing oral contraceptives, which have become available more recently, have a mineralocorticoid-derived progestational component. Previous studies hypothesized that mineralocorticoid-derived progestational compo­nent had higher effect on the venous thromboembolism. This study aimed to assessed combination oral contraceptive on the risk of venous thromboemboli.

Subjects and Method: A systematic review and meta analysis study was conducted by collecting articles from Google Scholar, PubMed, Research Gate, Scopus, Springer Link, and Science direct databases. Keywords used oral contraceptive” OR  “combined oral contraceptives” OR “risk factor” AND “venous thrombolism” OR “VTE” AND “family planning”. The inclusion criteria were full text case control studies published from 2000 to 2020. The articles were assessed using RevMan 5.3 software.

Results: A review from 9 studies showed that combination oral contraceptive elevated the risk of venous thromboemboli in family planning acceptors (aOR= 2.95; 95% CI= 1.80 to 4.84;  p<0.001). No publication bias was found in this study.

Conclusion: Combination oral contraceptive elevates the risk of venous thrombo­emboli in family planning acceptors.

Keywords: combination oral contraceptive, venous thromboemboli, family planning

CorrespondencePutri Yunita Sari. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: puyunita16@gmail.­com. Mobile: 08818794685.


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