Impact of COVID-19 on Maternal Immunity during Pregnancy: A Systematic Review

Finta Isti Kundarti, Kharisma Rahmadani


Department of Midwifery, Health Polytechnics, Ministry of Health, Malang, East Java




Background: There is an ongoing effort to understand transmission, incidence, disease pathogenesis and the short- and long-term impacts following COVID-19 infection. However, limited data about the clinical characteristics of pregnant women with COVID-19 have been reported. Given the maternal physiologic and immune function changes during pregnancy, pregnant women may be at a higher risk of being infected with SARS-CoV-2 and developing more complicated clinical events. This study aimed to describe the impact of COVID-19 on maternal immunity during pregnancy.

Subjects and Method: A systematic review was conducted using the PubMed, Proquest, and Science Direct databases. The inclusion criteria were prospective, and retrospective studies, published from 2020 to 2021, and the study subject was pregnant women of positive-confirmed COVID-19.

Results: A systematic review included 9 studies involving 620 study subjects. This study found that there was an immune response, such as immunoglobulin, lymphocytes, T cells, cytokines, interleukins, spike proteins, growth factors, TFH17, D dimers, and Tc2 cells, of COVID-19 in pregnant women.

Conclusion: There was an immune response of COVID-19 in pregnant women.


Keywords: pregnancy, COVID-19, immunity response

Correspondence: Finta Isti Kundarti. Department of Midwifery, Health Polytechnics, Ministry of Health, Malang, East Java, Indonesia. Email: Mobile: +62 8570­0100332.


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