Factors Affecting COVID-19 Vaccination Acceptance in Pregnant Women: A Meta-Analysis

Catur Setyorini1,2), Lilik Hanifah1,2), Anita Dewi Lieskusumastuti1,2)Aquartuti Tri Darmayanti2), Joko Tri Atmojo2)


1)Universitas Aisyiyah, Yogyakarta

2)School of Health Sciences Mamba’ul ‘Ulum, Surakarta



Background: Pregnant women infected with COVID-19 were more likely to develop more severe cases than those who are not pregnant. While existing international guidelines have not prioritized routine vaccination of all pregnant women due to a lack of data on safety and effectiveness, vaccination of pregnant women is still voluntary. It was essential to understand the factors that influence the acceptance of vaccination in pregnant women, which will significantly contribute to the return of society to a pre-pandemic state. This study aimed to analyze the reasons and factors that make pregnant women receive the COVID-19 vaccination.

Subjects and Method: This study was a meta-analysis. Online articles from 2010 to 2020 were searched from databases, including Pubmed, MEDLINE, EMBASE, CINAHL, and Science Direct. The PICO was as follows. Population= pregnant women. Intervention= age>25 years old, higher education, better knowledge. Comparison= age<25 years old, lower education, poorer knowledge. Outcome= acceptance of vacci­nation COVID-19. Keywords “pregnant” AND “COVID-19 vaccination”, “preg­nancy” AND “vaccination and factor associated”, “pregnant women” AND “acceptance and COVID-19 vaccination”. The data were analyzed by RevMan 5.3 application.

Results: A total of five articles were included for meta-analysis. The data showed that pregnant women having a bachelor’s degree or above (OR= 2.97; 95% CI= 1.98 to 4.45; p <0.001) and being over 25 years old (OR= 2.92; 95% CI= 2.22 to 3.85; p<0.001) were associated with an increased chance of COVID-19 vaccination acceptance. Although better knowledge about vaccination was influential, it was statistically non-significant (OR= 6.42; 95% CI= 0.83 to 49.52; p= 0.070).

Conclusion: The chance of COVID-19 vaccination acceptance increases with having a bachelor’s degree or above and being over 25 years old in pregnant women.

Keywords: vaccine, acceptance, COVID-19, pregnant women

Correspondence: Catur Setyorini. Universitas ‘Aisyiyah Yogyakarta. Jl. Siliwangi Jl. West Ringroad 63, Yogyakarta. Email: catur.ririn@yahoo.co.id. Mobile: 081229895846.

DOI: https://doi.org/10.26911/ICPHmaternal.FP.08.2021.12

Share this :

View PDF