Abstract
ABSTRACT
Background: Preeclampsia affects an estimated 4.6% of pregnancies globally. The etiology of preeclampsia is complex, and a role for maternal and fetal and/or paternal genetic determinants has been suggested by early family-based studies. The purpose of this study was to investigate risk factors of preeclampsia in pregnant women.
Subjects and Method: A case control study was conducted in Boyolali, Central Java, in October 2022. A sample of 164 pregnant women with gestational age 32-36 weeks, consisting of 82 pregnant women with preeclampsia and 82 pregnant women without preeclampsia was selected purposively. The dependent cariable was preeclampsia. The independent variables were parity, history of previous preeclampsia, family history of preeclampsia, and history of chronic hypertension. The data were obtained from antenatal health record and questionnaire. The data were analyzed using Chi square test.
Results: Multiparous (OR= 3.07; 95% CI= 1.14 to 8.30; p= 0.022) and previous pre-eclampsia (OR= 7.54; 95% CI= 1.64 to 34.56; p= 0.003) increased the risk of pre-eclampsia. No family history of preeclampsia (OR= 0.33; 95% CI= 0.38 to 0.54; p<0.001) and history of chronic hypertension (OR=0.46; 95% CI= 0.38 to 0.54; p<0.001) reduced the risk of preeclampsia.
Conclusion: Multiparous and previous preeclampsia increase the risk of preeclampsia. No family history of preeclampsia and history of chronic hypertension reduce the risk of preeclampsia.