Background: Chronic alcoholism has long been known to disrupt vitamin D metabolism. Excessive alcohol use in young adulthood can have a deleterious impact on vitamin D status later in life, including the development of osteoporosis in older age. This study aimed to review and estimate the association between excessive alcohol consumption and the risk of osteoporosis.
Subjects and Method: This was a meta-analysis conducted following the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guideline. The PICO research questions: Population: Elderly. Intervention: Excessive alcohol consumption. Comparison: Tolerable alcohol consumption. Outcome: Osteoporosis. Articles of cross-sectional studies were searched from PubMed, Google Scholar, and Science Direct. Keywords used for the article search were "alcohol consumption" AND osteoporosis AND elderly AND “cross-sectional". The inclusion criteria included full-text articles, reporting effect size by adjusted odds ratio (aOR), and being published from 2017 to 2023. Pooled aOR was estimated using Review Manager 5.3.
Results: The meta-analysis included 9 cross-sectional studies from Taiwan, China, and South Korea. There was a weak association between excessive alcohol consumption and the risk of osteoporosis in the elderly, and this association was statistically non-significant (aOR= 1.09; 95% CI= 0.97 to 1.23; p> 0.05).
Conclusion: The association between excessive alcohol consumption and the risk of osteoporosis is almost non-existent and statistically non-significant in the elderly.
Keywords: alcohol consumption, osteoporosis, elderly
Hallisa’tu Zahro. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: firstname.lastname@example.org. Mobile: +6281229451703.