Effect Of Exercise On Quality Of Life In PatientsWith Parkinson’s Disease: A Meta-Analysis


Authors

Khairunnisa Khairunnisa
Master’s Program in Public Health, Universitas Sebelas Maret
~ Author
Bhisma Murti
Master’s Program in Public Health, Universitas Sebelas Maret, Indonesia
~ Author

Abstract

Background: Exercise has shown remarkable potential benefits in people with Parkinson's disease, particularly in lowering symptoms and improving overall quality of life. This study aimed to estimate the effect of exercise on quality of life in patients diagnosed with Parkinson's disease.

Subjects and Method: This was a meta-analysis conducted using research questions formulated in the PICO format. Population: Patients diagnosed with Parkinson’s disease. Inter­ven­tion: Exercise. Comparison: No exercise. Outcome: Quality of life. Articles of randomized controlled trials (RCTs) were searched from PubMed and Science Direct. Keywords used were exercise AND “quality of life” AND “Parkinson’s disease” and “randomized controlled trial”. Quality of life was assessed using the Parkinson's Disease Questionnaire (PDQ-39). Data of mean values of each article were calculated using the RevMan 5.4.1.

Results: The meta-analysis included 11 RCTs. Exercises significantly lowered PDQ-39 scores (SMD= -0.49; 95%= -0.82 to -0.16; p= 0.004). It indicated that exercise improves the quality of life in patients with Parkin­son’s disease

Conclusion: Exercise improves the quality of life in patients with Parkinson’s disease.

Keywords: exercise, Parkinson’s disease, quality of life

 Correspondence:  Khairunnisa. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: khairunnisa1381@gmail.­com. Mobile: +62822­86674273.

References

Aarsland D, Batzu L, Halliday GM, Geurtsen GJ, Ballard C, Ray CK, Weintraub D (2021). Parkinson disease-associated cognitive impairment. Nature Reviews Disease Primers 2021. 7(1), 1–21. Doi: 10.1038/s41572021002803.

Bhalsing K, Abbas M, Tan L (2018). Role of physical activity in Parkinson’s disease. Annals of Indian Academy of Neurology. 21(4), 242. Doi: 10.-4103/AIAN.AIAN_169_18.

Brundin DK (2017). Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clin Geriatr. 176(5): 139–148. https://doi.org/10.1016/j.cger.2019.-08.002.

Cancela, JM, Mollinedo I, Montalvo S, Vila Suárez ME (2020). Effects of a high-intensity progressive-cycle program on quality of life and motor symptomatology in a Parkinson’s disease population: A pilot randomized controlled trial. Rejuvenation Res. 23(6): 508–515. Doi: 10.1089/rej.20-19.2267.

Chen K, Tan Y, Lu Y, Wu J, Liu X, Zhao Y (2020). Effect of Exercise on Quality of Life in Parkinson’s Disease: A Systematic Review and Meta-Analysis. Parkinson’s Dis. Doi: 10.1155/2020/3257623.

Choi Y, Kim D (2022). Effects of Task-Based LSVT-BIG Intervention on Hand Function, Activity of Daily Living, Psychological Function, and Quality of Life in Parkinson’s Disease: A Randomized Control Trial. Occup Ther Int. Doi: org/-10.1155/2022/1700306.

Cugusi L, Manca A, Bergamin M, Di Blasio A, Monticone M, Deriu F, Mercuro G (2019). Aquatic exercise improves motor impairments in people with Parkinson’s disease, with similar or greater benefits than land-based exercise: a systematic review. Doi: 10.1016/j.jphys.2019.02.003.

Dashtipour K, Johnson E, Kani C, Kani K, Hadi E, Ghamsary M, Pezeshkian S, Chen JJ (2015). Effect of exercise on motor and nonmotor symptoms of Parkinson’s disease. Parkinson’s Disease. Doi: 10.1155/2015/586378.

Ellis T, Rochester L (2018). Mobilizing Parkinson’s disease: The future of exercise. J Parkinson’s Dis. 8(s1), S95–S100. Doi: 10.3233/-JPD-181489.

Ferreira RM, Alves WM, Lima TA, Alves TG, Alves FP, Pimentel CP, Sousa EC, Cortinhas AE (2018). The effect of resistance training on the anxiety symptoms and quality of life in elderly people with parkinson’s disease: A randomized controlled trial. Arqui-vos de Neuro-Psiquiatria. 76(8), 499–506. Doi: 10.1590/00042-82x2018007.

Fothergill MN. (2023). The lived experience of stigma and parkinson’s disease in Kenya: a public health challenge. BMC Public Health. 23(1), 1–12. Doi: 10.1186/s12889-023-15278-7.

Gandolfi M, Tinazzi M, Magrinelli F, Busselli G, Dimitrova E, Polo N, Manganotti P, et al. (2019). Four-week trunk-specific exercise program decreases forward trunk flexion in Parkinson’s disease: A single-blinded, randomized controlled trial. Parkinsonism and Related Disorders, 64: 268–274. Doi: 10.1016/j.parkreldis.2019.-05.006.

Kurt EE, Büyükturan B, Büyükturan Ö, Erdem HR, Tuncay F (2018). Effects of Ai Chi on balance, quality of life, functional mobility, and Motor Impairment in patients with Parkinson’s disease. Disability and Rehabilitation. 40(7): 791–797. Doi.org/10.108-0/09638288.2016.1276972.

Li Z, Wang T, Shen M, Song T, He J, Guo W, Wang Z, Zhuang J (2022). Comparison of Wuqinxi Qigong with stretching on single-and dual-task gait, motor symptoms and quality of life in Parkinson’s disease: A preliminary randomized control study. Int J Environ Res Public Health. 19 (13). Doi: 10.3390/ijerph19138042.

Omar AS, Longhurst J, Stiles D, Dow-nard L, Martin S (2023). A meta-analysis of exercise intervention and the effect on Parkinson’s Disease symptoms. Neuroscience Letters, 801: 137162. Doi: 10.10-16/j.neulet.2023.137162.

Prenger MT, Madray R, Van Hedger K, Anello M, Macdonald PA (2020). Social Symptoms of Parkinson’s Disease. Parkinson’s Disease. Doi: 10.1155/2020/8846544.

Santos L, Fernandez-Rio J, Winge K, Barragán-Pérez B, González-Gómez L, Rodríguez-Pérez V, González-Díez V, et al. (2017). Effects of progressive resistance exercise in akinetic-rigid Parkinson’s disease patients: a randomized controlled trial. European J Phys Rehabil Med. 53(5), 651–663. Doi: 10.23736/-S1973-9087.17.04572-5.

Schenkman M, Moore CG, Kohrt WM, Hall DA, Delitto A, Comella CL. Effect of High-Intensity Tread-mill Exercise on Motor Symp-toms in Patients With De Novo Parkinson Disease A Phase 2 Randomized Clinical Trial. 800-45: 219–26. Doi: 10.1001/jama-neurol.2017.3517.

Silva-Batista C, de Lima-Pardini AC, Nucci MP, Coelho DB, Batista A, Piemonte ME, Barbosa ER, et al. (2020). A Randomized, Control-led Trial of Exercise for Parkin-sonian Individuals With Freez-ing of Gait. Movement Disorders. 35(9): 1607–1617. Doi: 10.1002/mds.28128.

Soke F, Guclu-Gunduz A, Kocer B, Fidan I, Keskinoglu P (2021). Task-oriented circuit training combined with aerobic training improves motor performance and balance in people with Par-kinson′s Disease. Acta Neuro-logica Belgica. 121(2): 535–543. Doi: 10.1007/s13760-019-0124-7-8.

Thieken F, van Munster M (2021). Deriving implications for care delivery in Parkinson’s disease by co-diagnosing caregivers as invisible patients. Brain Sciences. 11(12): 4–9. Doi: 10.3390/-brainsci11121629.

Tollár J, Nagy F, Kovács N, Hortobágyi T (2018). A High-Intensity Multicomponent Agility Intervention Improves Parkinson Patients’ Clinical and Motor Symptoms. Archives of Physical Medicine and Rehabilitation. 99(12): 2478-2484. Doi: 10.1016/j.apmr.-2018.05.007.

Van der Kolk NM, de Vries NM, Kessels RP, Joosten H, Zwinder-man AH, Post B, Bloem BR (2019). Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson’s disease: a double-blind, randomised controlled trial. The Lancet Neurology. 18(11), 998–1008. Doi: org/10.1016/S1474-4422(19)30285-6.

Zafar S, Yaddanapudi SS (2023). Parkinson Disease. StatPearls. 8, 1–13. https://www.ncbi.nlm.nih.-gov/books/NBK470193/. Accessed in August 16, 2023.

Zhao N, Yang Y, Zhang L, Zhang Q, Balbuena L, Ungvari GS, Zang YF, et al. (2021). Quality of life in Parkinson’s disease: A systematic review and meta-analysis of comparative studies. CNS Neuroscience and Therapeutics. 27(3), 270–279. Doi: 10.1111/-cns.13549.

How to Cite

Effect Of Exercise On Quality Of Life In PatientsWith Parkinson’s Disease: A Meta-Analysis. (2023). The International Conference on Public Health Proceeding, 8(01), 296-308. https://doi.org/10.26911/